When the clumsy Seymour Krelboyne spoils two flowers of a client, the owner of a small florist shop Gravis Mushnick is ready to fire him. However Seymour tells that he has mixed two plants of different breeds at home and created a hybrid named Audrey Jr. and Mushnick decides to give another chance to his employee. On the next day, Seymour brings Audrey Jr. that becomes the pride and joy of Mushnick, his other employee Audrey Fulquard and clients. Out of the blue, the flower seems to be dying and Seymour accidentally learns that she likes blood. One day, Seymour is upset since he does not know how to feed the flower and he walks along a railroad. When he throws a stone near a railroad track, he accidentally hits the head of a man that falls on the track and is a train runs over him. Seymour brings the pieces of the man to the shop and finds that the plant likes flesh. On the next morning, Audrey Jr. has grown and become the attraction of the shop. But how will Seymour feed his plant.